Chemical Found In Common Sweetener Damages Human DNA

In a recent study conducted by researchers at North Carolina State University, alarming findings have emerged regarding the potential health risks associated with a commonly used sweetener.

The study reveals that a chemical produced during the digestion of this sweetener, known as sucralose-6-acetate, is genotoxic, causing damage to human DNA.

The implications of this research raise concerns about the safety of consuming products containing sucralose and emphasize the need for a reevaluation of its regulation and usage.

The Role of Sucralose in Genotoxicity

• The Presence of Sucralose-6-Acetate: The study found that sucralose-6-acetate was not only present in trace amounts in the sweetener itself but also exceeded the toxicological concern threshold set by the European Food Safety Authority. This discovery highlights the potential risk it poses to human health even before its consumption and metabolism.
• Metabolites and Genotoxicity: Experiments conducted on human blood cells and gut tissues exposed to sucralose-6-acetate revealed its genotoxic effects. The chemical was found to break up DNA in the exposed cells, leading to potential genetic damage. Furthermore, the study observed increased genetic activity in gut cells associated with oxidative stress, inflammation, and carcinogenicity upon exposure to sucralose and its metabolites.
• Compromised Gut Integrity: Sucralose and sucralose-6-acetate were found to induce “leaky gut” in gut epithelial tissues, compromising the integrity of the gut wall. This compromise allows harmful substances to be absorbed into the bloodstream, posing additional risks to overall health.

Safety Concerns and Regulatory Measures

Susan Schiffman (the corresponding author of the study) raises significant concerns about the safety and regulation of sucralose. Accumulating evidence points to substantial risks associated with its consumption. Schiffman advises people to avoid products containing sucralose as a precautionary measure.

The World Health Organization (WHO) has recently advised against using non-sugar sweeteners, including sucralose, for weight control or reducing the risk of noncommunicable diseases. This advisory adds weight to the concerns raised by the North Carolina State University study.

Regulatory Reevaluation needed

The study’s findings highlight the urgent need to reevaluate the safety of sucralose and its metabolites. The current approval by the Food and Drug Administration (FDA) in 1998 may require reassessment in light of the newfound genotoxic effects. Consumer safety should be prioritized in the regulatory process.

In light of these findings, caution is warranted when considering the consumption of products containing sucralose. The accumulating evidence of significant risks should encourage consumers to prioritize their health and explore alternative sweetening options. Furthermore, regulatory bodies need to reevaluate

Paulo Montenegro
Categories: Medical
Tags: Health, Science